RESUMO
Hot aqueous extract of bark of Anacardium occidentale (Cashew), commonly used in Trinidadian folk medicine for the treatment of diarrhoea was evaluated for antidiarrhoeal activity. The extract inhibited castor oil-induced diarrhoea in rats as judged by a decrease in the number of wet faeces in the extract-treated rats. The extract was also inhibited the propulsive movement of intestinal contents in mice. The extract showed no direct effect on the isolated guinea-pig ileum, however, it inhibited in a dose-related manner the contractile effects of acetylcholine, histamine, and 5-hydroxytryptamine. The inhibitary effects on these agonists were non competitive in nature. Phytochemical tests revealed the main constituents as tannin, steroids, triterpenoid and carbohydrates. The results indicates that action of A. occidentale bark extract could be through a combination of inhibition of elevated transmitter released and reduced propulsive movement of the small intestine. There is merit in the folk medicinal use of the extract (AU)
